mRNA - Process Development Engineer - Scientist - Drug Substance - Vaccines
Waltham, Massachusetts
Overview
From Research and Development to Sales and Marketing, Sanofi offers a wide range of possibilities. Discover our open positions and become a health journey partner.
Success Profile
Do you have what it takes for a successful career with Sanofi?
- Courageous
- Results-driven
- Proactive
- Problem-Solver
- Leadership
- Team player
Culture: Play to Win
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Growth
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Innovation
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Efficiency
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Collaboration
Benefits
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Health & Wellness
Comprehensive coverage including medical, dental, vision, and health and wellness programs.
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Financial
Sanofi wants to ensure employees are equipped for financial health, Sanofi provides a competitive 401K Match program and Financial Wel-Being Tools and Programs.
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Culture
At Sanofi, we demonstrate our commitment to inclusion and diversity through Culture groups and programs. There are many ways to make a difference and connect with other Sanofi employees: including ERG groups and 2 PAID days off to Volunteer.
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Work/Life Balance
Sanofi provides significant Work/Life benefits to help you excel beyond the workday. Including Workplace Flexibility through part‑time, remote work, flex‑time and job share options.
Quote
"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."
Shannon Resetich
US Head Rare Diseases & Blood Disorders
"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."
Mouhamed Gueye
US Head Medical Rare Blood Disorders
Responsibilities
In the race for the future of health – The Sanofi mRNA Center of Excellence (CoE)
At Sanofi, we chase the miracles of science, and we know mRNA has a role to play in the future of health. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines and treatments for more people faster than before.
That’s why we’re looking for bold, optimistic world-changers to join our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 450 dedicated employees, and focusing on implementing an integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.
Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology!
About the Opportunity
As a Process Development Engineer/ Scientist in the Global Drug Substance Development group you will focus on CMC development, optimization and scale-up of mRNA synthesis and purification processes with the ultimate goal of transferring at scale methods to either the internal or external manufacturing team for GMP manufacturing of mRNA drug substance.
In this role you will….
Develop scalable bench scale processes for mRNA drug substance.
Design and perform experiments and analyze results.
Keep detailed records using an electronic laboratory notebook.
Use QbD principles to develop and improve scale down models for mRNA GMP drug substance production to support process understanding, CPP/KPP identification, and robustness studies (PAR and NOR validation) etc.
Analyze, interpret, and summarize results in reports and presentations.
Understand routine and complex analytical methods while working toward continual improvement.
Proactively collaborate with other groups or sites in transfer of information, materials, and drug substance technology
Support and contribute to IND filings/regulatory documentation.
Train new research associates and other junior team members
About you
Biochemistry, engineering, or related degree; PhD with 0 + years, MS with 3 + years, or BS with 5 + years of relevant industrial experience.Experience in large molecule drug substance development is required.
Experience of biologics purification using chromatography is required. Other downstream experiences, for instance enzyme reactions, mixing, depth filtration, tangential flow filtration, is preferred.
Previous work with mRNA (handling/isolation/quantification/characterization) is desired.
Capable of working in a collaborative team environment both within group and on interdisciplinary teams
Strong analytical and problem-solving skills
Ability to work in a fast-paced environment.
Good communication and interpersonal skills.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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Pursue progress, discover extraordinary
Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people.
At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.
Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com!
