Scientist Gene Therapy Immunology
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"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."Shannon Resetich US Head Rare Diseases & Blood Disorders
"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."Mouhamed Gueye US Head Medical Rare Blood Disorders
The Genomic Medicine Unit is seeking a highly motivated candidate for a Scientist role that will help build innovation in gene therapy immunology.
Host immune response to non-viral gene therapy and adeno-associated viral vectors (AAV) is a key challenge for clinical adoption. The successful candidate will work transversally with members of various research groups including capsid engineering, large molecule research and computational biology teams to develop strategies aimed at minimizing adaptive immune responses to LNP and AAV. The candidate will explore the use of Sanofi’s proprietary immunomodulatory molecules to dampen host immunological response to gene therapy administration. Participation will provide the candidate a tangible opportunity to contribute to development of novel genomic medicine approaches for rare diseases with unmet need.
Test Sanofi molecules in vivo and ex vivo to determine immune modulation by these molecules with a focus on adaptive immune responses
Develop assays for determining adaptive immune responses to AAV and LNP in human/mouse/NHPs primary cells with focus on T cells/Tregs
Responsible for independently executing experiments in a time sensitive manner
Develop and maintain a culture of teamwork and collaboration.
Ph.D. in immunology or immunology-related discipline
Strong presentation and communication skills and ability to work in a team-oriented environment
Knowledgeable and skilled in designing and conducting in vivo mouse studies and ex vivo cell-based assays for small molecules/biologics for immune-modulatory activity
Extensive experience with animal research
Ability to manage multiple projects in parallel, communicate clearly and effectively and build open and collaborative relationships with scientists from multiple groups
Relevant industry experience
Prior experience in complement cascade immunology
At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
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