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Scientist Gene Therapy Immunology

Waltham, Massachusetts

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Overview

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    Comprehensive coverage including medical, dental, vision, and health and wellness programs.

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Quote

"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders

Responsibilities

Position Overview

The Genomic Medicine Unit is seeking a highly motivated candidate for a Scientist role that will help build innovation in gene therapy immunology.

Host immune response to non-viral gene therapy and adeno-associated viral vectors (AAV) is a key challenge for clinical adoption. The successful candidate will work transversally with members of various research groups including capsid engineering, large molecule research and computational biology teams to develop strategies aimed at minimizing adaptive immune responses to LNP and AAV. The candidate will explore the use of Sanofi’s proprietary immunomodulatory molecules to dampen host immunological response to gene therapy administration. Participation will provide the candidate a tangible opportunity to contribute to development of novel genomic medicine approaches for rare diseases with unmet need.

Key Responsibilities

  • Test Sanofi molecules in vivo and ex vivo to determine immune modulation by these molecules with a focus on adaptive immune responses

  • Develop assays for determining adaptive immune responses to AAV and LNP in human/mouse/NHPs primary cells with focus on T cells/Tregs

  • Responsible for independently executing experiments in a time sensitive manner

  • Develop and maintain a culture of teamwork and collaboration.

Basic Qualifications

  • Ph.D. in immunology or immunology-related discipline

  • Strong presentation and communication skills and ability to work in a team-oriented environment

  • Knowledgeable and skilled in designing and conducting in vivo mouse studies and ex vivo cell-based assays for small molecules/biologics for immune-modulatory activity

  • Extensive experience with animal research

  • Ability to manage multiple projects in parallel, communicate clearly and effectively and build open and collaborative relationships with scientists from multiple groups

Preferred Qualifications

  • Post-doctoral

  • Relevant industry experience

  • Prior experience in complement cascade immunology

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society. 

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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