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Principal Scientist Enzymology

Waltham, Massachusetts

Sanofi, a global healthcare leader, discovers, develops, and distributes therapeutic solutions focused on patients' needs. With 12 locations in Massachusetts, many located within close proximity to Boston, you'll have easy access to public transportation, popular restaurants, some of the best education, and most of all the history.

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    Comprehensive coverage including medical, dental, vision, and health and wellness programs.


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    Sanofi is eager to further your development and expertise in an ever challenging environment.


    Sanofi understands the importance of family. We offer a variety of support including maternity/paternity leave.


    Enjoy 3 weeks’ vacation and paid holidays, including company shutdown at the end of every year!


    Importance of life outside of the office is valued at Sanofi.

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We are seeking a highly motivated Enzymologist to join the In Vitro Biology Group (Waltham, MA) as a Senior Scientist. The successful candidate will join a multidisciplinary research and development team dedicated to small molecule drug discovery. The candidate will be responsible for developing enzymatic assays for primary or secondary screening, run mechanism of action enzymatic assay to provide insightful SAR (structure activity relationship). The candidate is also expected to support screening (HTS/MTS) and be familiar with automation technologies

As an important member of high value project teams, the candidate will work collaboratively with medicinal chemists, biologists, DMPK scientists, etc., presenting his/her results at team meetings and influencing decision-making discussions. With an appropriate sense of urgency, the successful candidate will bring valuable experiences to address scientific questions, and is expected to be open-minded to learning new skills and new ways to streamline workflows and drive priorities.

 Basic Qualifications:

 Ph.D. with 5-7 years of professional experience developing/running enzyme assays in an industrial environment (Biotech/Pharma).  Experience in variety of assay formats used in the industry and a strong background in enzymology required.  Experience with Biophysics, understanding of SAR and correlating enzyme data with DMPK assays as well as background in medicinal chemistry background is a plus.

Preferred Qualifications:

Strong enzymology background; experience working in a multidisciplinary drug discovery team is highly desirable. Experience with assay validation in a biotech/Pharma setting is a plus. Strict attention to detail and excellent communication (oral and written) skills are required. The candidate must be motivated to excel in both individual and team environments.


Ph.D. with 5-7 years of professional experience developing enzymatic assays in the biotech/pharmaceutical environment.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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