Postdoctoral Fellow Non-Viral Gene Therapy

The Genomic Medicine Unit is seeking a highly motivated Postdoctoral Fellowship candidate that will help build innovation in the area of tissue-targeted lipid nanoparticle delivery.

The successful candidate will work transversally with members of various research groups including non-viral research, large molecule research, molecular biology, and bioinformatic teams to optimize delivery of DNA cargo and nanoparticle formulations to specific tissues. Participation in this project will provide the candidate a tangible opportunity to contribute to development of novel genomic medicine approaches for rare diseases with unmet need. The candidate will also join the Global Sanofi Postdoctoral program and community in which there are opportunities for networking, learning, career development and mentorship.  The Global Sanofi Postdoctoral program offers several activities, including ‘Lunch & Share’, a forum for data sharing and feedback, “Lunch & Learn” with presentations from subject matter experts across Sanofi, ‘Fireside Chats’ comprising career stories and advice from Sanofi leadership, and an annual Postdoctoral symposium which provides the opportunity for fellows to showcase their research and themselves to the entire Global R&D Organization. 

Key Responsibilities:

• Design and execute experiments to evaluate and optimize novel non-viral delivery methodologies using lipid nanoparticle (LNP) and other nanoformulations.

• Evaluate novel gene delivery formulations effectiveness following in vivo and  in vivo.

• Establish creative strategies for delivering lipid nanoparticles that target specific tissues with an initial focus on using peptides and antibodies

• Develop analytical assays for determining LNP distribution in tissues

• Develop approaches to optimize DNA cargo delivery and establish approaches for testing delivery of cargo in cells and tissues

• Collaborate with wet-lab and computational scientific teams and help the group champion projects from discovery to early clinical development.

Required Qualifications:

• PhD in Biology or Chemistry

• Ability to develop and troubleshoot experimental procedures

• Ability to perform animal research

• The ability to manage multiple projects in parallel, communicate clearly and effectively and build open and collaborative relationships with scientists from multiple groups is essential

• Strong interested in biology, medicine and caring for developing novel therapeutic intervention strategies for patients with unmet disease conditions

Preferred Qualifications:

• Working knowledge with lipid nanoparticles and nucleic acid delivery is a plus but not required.

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society. 

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.  

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