mRNA - Computational Biology - Senior Data Scientist - Vaccine
Waltham, Massachusetts, Marcy-l'Étoile, France
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In the race for the future of health – The Sanofi mRNA Center of Excellence (CoE)
At Sanofi, we chase the miracles of science, and we know mRNA has a role to play in the future of health. And while the pandemic has shaken up our industry, creating new opportunities and risks, we believe the acceleration of innovation with mRNA technology means vaccines and treatments for more people faster than before.
That’s why we’re looking for bold, optimistic world-changers to join our mRNA Center of Excellence. We’re investing €400m a year into the new Center, hiring a team of 450 dedicated employees, and focusing on implementing an integrated end-to-end mRNA vaccine capabilities and research with R&D, digital and CMC teams.
Bring your ambition and optimism and join us on our journey to discover and deliver transformative medicine to patients through the advancement of our cutting-edge mRNA technology!
About the Opportunity
As an experienced mRNAComputational Biologist, you willlead data analysis and modeling efforts for computational biology, systems immunology and systems vaccinology in the mRNA vaccine and therapeutic domains as part of the Data and Computational Science team in the mRNA CoE.This team brings end to end data integration and advanced analytics (pre-clinical, biomarkers, CMC, clinical) in the mRNA CoE. Deploying and exploiting digital solutions (AI/machine learning, data, analytics) to integrate the full data value chain, extracting actionable information for a move to a full data driven strategy and decision-making process, to increase probability of success and to accelerate mRNA vaccines and therapeutics development and launch. In this position, you will work in collaboration with other mRNA CoE platforms scientific experts located in the US and in France, bringing practical knowledge and experience in applying bioinformatics, statistical and computational methods to pre-clinical and translational research data for understanding and optimizing mRNA vaccines and therapeutics. We look for data scientists/computational biologists with breadth of knowledge and experience delivering insights from data through statistical data analysis, machine learning, simulation & modeling and data visualization.
In this role you will:
Represent the mRNA CoE Data and Computational Science team in platform and project teams as subject matter expert and contribute to the Research data strategy
Design, develop and validate robust solutions and pipelines leveraging bioinformatics, statistical models, multivariate analysis etc. for pre-clinical and translational data
Perform exploratory data analysis, hypothesis generation and validation through data integration, advanced analytics, and visualization of mRNA vaccine design parameters, high dimensional immunological, -omics and pre-clinical and clinical data (e.g. immunogenicity, reactogenicity)
Explore and analyze proprietary and public data for mRNA vaccines mode of action understanding and optimization, biomarkers; generate hypotheses for additional testing
Collaborate with scientific partners to advise on study design, readout selection and data formats, data analysis and modeling to generate actionable, reproducible, and interpretable insights
Bring broad knowledge and expertise in statistics, data science, machine learning and modeling to project and mRNA platform teams.
Prepare and publish scientific papers and congress reports.
Demonstrate good software engineering practices
Proactively identify, assess, and internalize emerging technologies and methods
Generate IP and participate in the drafting of patent filings
Competencies / Requirements for position
PhD in Bio-statistics, Bioinformatics, Data and Computer Sciences, Systems Immunology, Computational Biology or equivalent.
Skills to collect, integrate, mine and analyze complex biological data and translate them into testable hypotheses. Demonstrated track record including publications developing solutions and delivering insights from data using multivariate analysis, statistical modeling and bioinformatic methodologies in one or more of the following areas:
Computational biology, Systems immunology, vaccinology and immuno-genomic: bioinformatics and genomics (including single cell genomics) for disease understanding, immunological questions and/or vaccinology (scRNASeq, sc TCR/BCR seq, CITE-Seq etc)
Data mining, multivariate statistics and machine for biomarkers discovery and validation
Strong programming (R and Python), data analytics and modeling skills with experience developing data visualization solutions, process & workflow automation and deploying solutions to the cloud.
Proven ability to work independently to learn new technologies, techniques, processes, languages, platforms, systems
Strong combination of theoretical knowledge, analytical and critical thinking, and creative problem-solving skills. Solid understanding of statistical methods relevant to large scale analysis of biological data sets
Good communication scientific writing and presentation skills, ability to simplify complex problems and communicate complex solutions in a simple and effective manner
Good networking skills and fluent interactions with one or more scientific communities
Understanding of vaccine discovery and development processes is a plus, as well as familiarity with RNA biology and RNA-centric techniques/methods
Fluent in English (French is a plus)
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. This position will require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.
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