Postdoctoral Fellowship: ALS Job at University Recruitment at SanofiLocation Tucson, Arizona Job Category University Recruitment Requisition Number 39063
Sanofi, an integrated global healthcare leader, discovers, develops and distributes therapeutic solutions focused on patients’ needs. Sanofi has core strengths in the field of healthcare with seven growth platforms: diabetes solutions, human vaccines, innovative drugs, consumer healthcare, emerging markets, animal health and the new Genzyme.
Dr. Paul August ( Sanofi )
The postdoctoral fellow will progress a research discovery project to differentiate human ALS patient iPSCs (inducible pluripotent stem cells) and fibroblasts into spinal motor neurons that recapitulate the pathology of the ALS disease phenotype. They will establish cellular assays in collaboration with an academic partner in Los Angeles (Dr. Justin Ischida - USC) and evaluate compounds from the Sanofi compound collection in ALS patient models in vitro. The scientific objective of the fellowship is to develop and utilize these pathophysiologically relevant cellular models of motor neuron disease to support the identification of drug targets and tool compounds that may demonstrate therapeutic utility in vivo. These targets and compounds will be evaluated for their ability to modulate ALS in animal models of disease. The fellowship is part of a research grant from the Department of Defense to advance a new initiative to identify therapeutic approaches for ALS in patients. The post-doctoral fellow at Sanofi will have a close interaction with academia in a preclinical industry setting during the term of the three year funded fellowship. The interdisciplinary training will facilitate the development of researchers with a translational medicine mindset and deep expertise in “disease in a dish” drug discovery models. It is expected that several publications will result from this work.
Applicants should hold a Ph.D. or equivalent, with expertise in relevant areas cellular biology, isolation, generation and propagation of stem cells for in vivo pharmacology assays is critical. Experience with high content imaging and small molecule pharmacology studies are desireable. The candidate should have experience with animal models of disease and be capable of performing some animal pharmacology studies. It is expected that the candidate will demonstrate a record of excellence in research and collaborative potential. Strong written and verbal skills in English are essential. The candidate should be authorized to work in the United States of America.