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Scientist I – Platform Innovation

San Diego, California



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"One of the best things about Sanofi Genzyme is the consistently fun and dynamic work environment that I get to be a part of."

Kristin Ouimet Regional Business Manager

"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders


Synthorx, a Sanofi company, has developed a semi-synthetic organism. This organism was derived from E. coli and engineered to store an unnatural base pair in its DNA, which it transcribes into RNA and uses during translation to produce proteins with unnatural amino acids. Synthorx is currently using this bacterial semi-synthetic organism to develop next generation protein therapeutics. We are now seeking scientists to join the Synthorx Platform Innovation team to work towards the creation of eukaryotic-based semi-synthetic organisms. As efficient translation has already been demonstrated in CHO and HEK cells (A. X.-Z. Zhou, K. Sheng, A. W. Feldman, F. E. Romesberg. 2019 Progress toward Eukaryotic Semisynthetic Organisms: Translation of Unnatural Codons. J Am Chem Soc 141:20166–20170), the successful applicant will be part of a team that first focuses on optimizing the expression of a heterologous nucleotide transporter that imports the required unnatural triphosphates. With the triphosphates made available within the cell, the team will then focus on characterizing/optimizing replication and transcription. Finally, the semi-synthetic eukaryotic cell will be used to produce proteins containing non-canonical amino acids for development as next generation therapeutics. The successful candidate will also aid in the coordination, planning, and execution of existing and new collaborations with other groups within Sanofi to explore the development of novel therapeutics for different applications.

Key Responsibilities

Explore and optimize the expression of different nucleotide transporters in eukaryotic cells (e.g. yeasts (S. cerevisiae, P. pastoris) or human cell lines (CHO, HEK).

Perform nucleotide-uptake assays.

Collaboratively design and implement experiments to characterize and/or optimize the retention of the unnatural base pair during DNA replication and transcription.

Characterize the fidelity with which non-canonical amino acids are incorporated in expressed proteins.

Support efforts to optimize the production of proteins with non-canonical amino acids, including one or multiple instances of the same or two different non-canonical amino acids.

Basic Qualifications

PhD in appropriate field. No postdoctoral experience required.

Experience with eukaryotic genetics (e.g. yeasts (S. cerevisiae, P. pastoris) or human cell lines (CHO, HEK).

Experience with, and general understanding of, protein trafficking, DNA replication, and/or transcription in eukaryotic cells.

Experience with, and general understanding of, heterologous protein expression in eukaryotic cells.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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