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Scientist Upstream Development - Vaccine

Meriden, Connecticut



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The Upstream Process Development Group, as a part of Process Development Department, has responsibilities to support the development and continuous improvement of bioprocess production for manufacturing Flublok influenza and the COVID-19 vaccines.  It encompenses the development of production processes (Batch and Fed-Batch) for seasonal strain changes, evaluation and improvements of process parameters.  The Upstream group provides also support to other departments such as MFG as needed.


Primary responsibility will be to assist in the development and execution of experiments in all upstream activities through SOPs and documented protocols.  Duties will include cell culture maintenance, virus expansion and preparation of seed and cell scale-up for bioreactor experiments. One of the key primary responsibilities will be to perform process scale up, evaluate different clones for the infection kinetics and yield perspective. In addition, the scientist will be interacting with other functions to determine the yield and purity of the protein expressed.  Secondary responsibilities will be to compile and analyze experimental data for biochemical parameters using the BioNova, spent rate for the amino acids using the Rebel system, and maintain the database.  Knowledge and experience in process modelling is a huge plus. Duties will include but not limited to operation and maintenance of bioreactors through execution of SOPs and protocols, data mining and analysis.  Tertiary responsibilities will be to assist in basic laboratory analytical techniques.  Duties will include SDS-PAGE, Western blots, SRID assay, pH meters, etc.  The candidate is capable of identifying and troubleshooting the USP operation problems in small-scale bioreactors and participates in the process improvement program.

Responsibilities include:

  • Process scale up from 2L to 10L to 200L using various types of bioreactor such as glass, and single use bioreactor. It will be important to generate the process scale up data to ensure that we can perform and predict the behavior of our clone in bioreactors.

  • Write experimental plans, protocols and reports.

  • Records process development activities and results in PD notebooks and spreadsheets.

  • Responsible for completing paperwork for each task, cleaning procedures, aseptic processing techniques.

  • Conduct routine preventive maintenance of bioreactors and other upstream equipment as needed.

  • Maintains laboratory notebook documentation in accordance with PD department rules.

  • Maintains laboratory inventory and equipment.

  • Assist in the execution of all tasks requested by internal and external collaborations/Customers.

  • Participates in the cleaning and maintenance of the bioreactor room

  • Assist in updating and maintaining the schedule.

  • Assist in analyzing upstream data.

*Key Responsibilities may differ among employees with the same job title and may change over time, in accordance with business needs.


  • MS in Biology, Chemistry, Biochemistry, Chemical Engineering, or similar field of study with 5-8 years of experience OR

  • Ph.D. in Biology, Chemistry, Biochemistry, Chemical Engineering, or a similar field of study and 2-5 years of experience AND

  • Experience in cell culture procedures and associated aseptic techniques.

  • Experience in process development and process scale-up.

  • Fluent in both written and spoken English.

  • Strong verbal and written communication skills.

  • Able to work effectively in a collaborative team and to prioritize assignments.


  • Knowledge and experience in process modelling is strongly preferred.

  • Experience in molecular biology techniques and protein chemistry

  • Hands-on experience with bioreactors and recombinant protein production is strongly desired.

  • Experience in operation of disk stack centrifuge

  • General laboratory skills, and experience in process controls will be highly desirable.

  • Experiences in the Biotechnology and pharmaceutical industry

Work Related Activities:

  • Willing to work changing work schedules and hours as needed

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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