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Principal Scientist, Analytical Development

La Jolla, California

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Overview

This is where ideas are pioneered and innovation takes shape. Where being a health journey partner takes shape — and where you can help bring ideas to life. Research & Development is the heart of our business. The clinical research, clinical development and clinical trials that are essential to new product development all happen here. Preclinical drug safety is rigorously tested and our program management teams ensure everything stays on track. Together, our R&D team ensures that our pipeline is protected and productive — and that the early stages of development run smoothly and effectively. Come be part of this journey.

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Benefits

  • Health & Wellness

    Comprehensive coverage including medical, dental, vision, and health and wellness programs.

  • Financial

    Sanofi wants to ensure employees are equipped for financial health, Sanofi provides a competitive 401K Match program and Financial Wel-Being Tools and Programs.

  • Culture

    At Sanofi, we demonstrate our commitment to inclusion and diversity through Culture groups and programs. There are many ways to make a difference and connect with other Sanofi employees: including ERG groups and 2 PAID days off to Volunteer.

  • Work/Life Balance

    Sanofi provides significant Work/Life benefits to help you excel beyond the workday. Including Workplace Flexibility through part‑time, remote work, flex‑time and job share options.

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Quote

"My family is everything to me. They are proud of the work I do, educating the community and ensuring that no Pompe patient is left behind."

C. Richard Cioci Clinical Science Associate – Pompe Ontario East & Atlantic

"I am continually impressed at the dedication that Sanofi has to the patients for whom we provide solutions."

Suncére Hernandez Area Business Manager, Multiple Sclerosis

"I give thanks to my powerhouse team for reminding me that I have a support system behind me, pushing me forward."

Bob Shustack Head of Global Support Functions Finance, North America

Responsibilities

Principal Scientist –Analytical Development
Synthorx, a Sanofi Company, employs a novel synthetic biology platform for the discovery
and development of transformational protein therapeutics for the treatment of cancer and
autoimmune disorders. We are hiring a Principal Scientist with experience in protein
analytics and in-depth knowledge of characterization to join the CMC team to advance drug
candidates through clinical development and accelerate IND-enabling activities. The
qualified candidate will report to the Senior Director of CMC Analytical and Formulation
Development.
Key Responsibilities:
• Design and implement methods for the characterization of PEGylated proteins,
mAbs, antibody fragments and proteomics using state of art analytical technologies
including LC/MS and MS/MS
• Apply extensive scientific knowledge and practical experience to develop separation
methods, e.g. RP, IEX, HILIC, SEC and Protein A affinity chromatography for
quantitative and qualitative analysis
• Apply extensive hands-on experience with various instrument and software
including LC-Qtof mass spectrometry, nanoLC-MS/MS, Orbitrap MS, LC-SQD2, UVVIS
spectrophotometer, etc. to support method development and quick data
turnaround
• Perform LC-MS/MS method development in conjunction with optimal separation
technologies to identify and quantitate Host Cell Proteins (HCPs) supporting HCP
assay development and downstream process development
• Support characterization of PTMs and relative quantitation of unnatural amino acid
incorporation throughout lead to drug candidate steps
• Develop labelled and label-quantitative peptide assays to support fidelity
(misincorporation) and titer methods throughout the product development cycle
• Participate in comparability studies to establish product attribute profile and
support process characterization and validation
• Collaborate with internal teams and external CMOs or CROs and provide support to
different activities as needed
• Manage priorities, plan experiments, conduct analysis and report results to project
teams
• Prepare research reports and presentations for team meetings, and draft laboratory
standard operation procedures
Education/Experience:
• Ph.D. in analytical chemistry or related disciplines with a minimum of10 years
relevant industry experience
• Substantial scientific knowledge and hands-on experience in protein structure
elucidation, identification and quantitation of related impurities or PTMs and
degradants using LC-MS/MS
• Practical experience in protein or peptide quantitation by mass spectrometry using
a label or label-free technologies
• Masters software and bioinformatic strategies for protein identification and
quantitation
• Experience in in-vivo and ex-vivo PK/PD assays, metabolite identification,
automation in high throughput LC/MS based assay is preferred
• Working knowledge of HDX-MS is a plus
• Ability to work with different LC-MS systems and software, performing routine
maintenance and troubleshooting
• Programing using Visual Basic, PE Multiprobe HT or Tecan liquid handler is a plus
• Familiarity with ICH, USP and FDA requirements for method development validation
• Ability to work in a fast-paced and team-orientated environment, and commitment
to a collaborative and professional work environment
• Excellent organization skills and ability to multi-task and manage priority
• Excellent computer skills: proficiency with Microsoft Excel and PowerPoint required
• Good oral and written communication skills a must

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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