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Associate Scientist, Molecular Biology and Strain Engineering (SYN)

La Jolla, California



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Scientist – Molecular Biology and Strain Engineering

Synthorx, a Sanofi company, is a biopharmaceutical company dedicated to delivering new biologic

medicines to patients. Synthorx is applying a revolutionary synthetic biology technology based on an

expanded DNA code to create designer protein-based medicines. We are seeking a dynamic and

rigorous Associate Scientist to join our team to help design, build and test improvements to our platform

to enhance production of therapeutic proteins, and to support projects focused on the identification of

novel molecules for immuno-oncology. The ideal candidate will bring extensive experience in molecular

biology and protein expression, and strong expertise in developing strategies and methods for high-level

protein production.

Key Responsibilities:

This position will be an integral part of our strain design and engineering group. The successful

candidate will play a critical role in the design, planning, performance, and analysis of molecular biology

and microbiology experiments to optimize the expression of difficult to express therapeutic protein

candidates using the Synthorx technology. Regular activities will include designing and performing

molecular biology for cloning, transforming microbial strains and generating/testing novel constructs and

strains for high-level protein expression. We hope to bring in an individual with strong initiative and desire

to make a positive impact on the team. The ideal candidate will demonstrate the ability to effectively work

within a highly collaborative environment with other scientific members and make individual contributions

of high impact.


  • PhD or BS in biomedical sciences and 10 years of lab experience or related field; or MS and 8
  • years in biomedical sciences or related field.
  • Proven expertise with engineering E. coli is strongly preferred.
  • Knowledge and practical experience in the following is particularly advantageous:
  • Experience with protein expression construct design and optimization.
  • Command and extensive experience in DNA assembly methods.
  • Hands on experience testing and optimizing recombinant protein expression in microbial
  • hosts.
  • Experience in development or application of higher-throughput methodologies for protein
  • expression screening.
  • Experience with orthogonal translation systems and hands-on experience with amber
  • suppression is a plus.
  • Highly creative and innovative with a drive to generate and translate new ideas into practical
  • advances.
  • Self-motivated and independent, but demonstrated ability to coordinate and work well as part of a
  • research team.
  • Ability to work well in sight of aggressive timelines and excellence in multitasking.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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