Skip to main content

Search Jobs

Senior Scientist/Principal Scientist, Oligonucleotides

Framingham, Massachusetts, Frankfurt am Main, Germany



From Research and Development to Sales and Marketing, Sanofi offers a wide range of possibilities. Discover our open positions and become a health journey partner.

Back to Job Navigation (Overview)

Success Profile

Do you have what it takes for a successful career with Sanofi?

  • Courageous
  • Leadership
  • Proactive
  • Problem-Solver
  • Results-driven
  • Team player

Back to Job Navigation (Success)

Culture: Play to Win

  • Woman looking through a microscope


  • Scientists discussing lab work


  • Doctor using new technology


  • Woman using dry eraser marker drawing up business plans on glass



  • Health & Wellness

    Comprehensive coverage including medical, dental, vision, and health and wellness programs.

  • Financial

    Sanofi wants to ensure employees are equipped for financial health, Sanofi provides a competitive 401K Match program and Financial Wel-Being Tools and Programs.

  • Culture

    At Sanofi, we demonstrate our commitment to inclusion and diversity through Culture groups and programs. There are many ways to make a difference and connect with other Sanofi employees: including ERG groups and 2 PAID days off to Volunteer.

  • Work/Life Balance

    Sanofi provides significant Work/Life benefits to help you excel beyond the workday. Including Workplace Flexibility through part‑time, remote work, flex‑time and job share options.

Back to Job Navigation (Rewards)


"My family is everything to me. They are proud of the work I do, educating the community and ensuring that no Pompe patient is left behind."

C. Richard Cioci Clinical Science Associate – Pompe Ontario East & Atlantic

"I am continually impressed at the dedication that Sanofi has to the patients for whom we provide solutions."

Suncére Hernandez Area Business Manager, Multiple Sclerosis

"Patients are at the center of our work. Our teams focus on advancing transformational therapies, and expanding patient access to our medicines."

Mouhamed Gueye US Head Medical, Rare Blood Disorders



Senior/Principal Scientist will be part of the oligonucleotides subject matter expert team and is responsible for providing technical and program management leadership by performing the following duties:

  • Leads LCM programs by representing MSAT in global Industrial Affairs (IA) cross-function and cross-site product teams. 

  • Provides vital technical insight to global MSAT programs including process and analytical development, process control strategy, continuous process verification, manufacturing support and improvement, global tech transfer and validation. Leads LCM activities in MSAT project teams.

  • Provides scientific guidance to MSAT Lab operations regarding the design, set-up, and execution of scale-down experiments. Participates in Lab results analysis and bridging between the experimental outputs and manufacturing practice

  • Participates in monitoring the health of manufacturing process capability across the product portfolio manufactured in internal/partner Industrial network to identify common trends or major risks in their expert domain and recommends preventative or remedial actions to Manufacturing, Molecular Stewards or Site teams as appropriate for implementation

  • Works with cross-functional teams to resolve deviations, align global control strategies (raw materials, process, methods, equipment), and mitigate potential risks.

  • Support QC and regulatory teams during health authority audits and prepare for supportive  regulatory documents for responses or new filings. May lead internal documentation and preparation of reports required for regulatory documents

  • Provides technical mentorship and training to Lab operation team and manufacturing team as needed


  • Degree in chemistry, chemical engineering or other relevant discipline


  • BS with 10+ years of professional experience


  • MS with 7+ years of professional experience


  • PhD with 5+ years of professional experience


  • Minimum of 4 years of hands-on experience in oligonucleotide synthesis and/or commercial manufacturing operations


  • Process development experience with synthesis of oligonucleotides and small molecules
  • Knowledge across technical domain (synthesis, process HPLC, formulation, lyophilization)
  • Prior experience with leading projects and mentoring technical staff
  • Excellent verbal and written communication skills
  • Highly motivated individual with the ability to work independently as well as on a cross-functional and cross-site teams


Domestic and International travel required

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

You have not recently viewed any jobs.

You have not saved any jobs.

Back to Job Navigation (Related Jobs)

Join Our Talent Community

Join our Talent Network and get Sanofi communications delivered to your inbox. By submitting your information, you acknowledge that you have read our privacy policy and consent to receive email communication from Sanofi.

Sign Up