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Scientist, MSAT Pilot Lab

Framingham, Massachusetts

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"One of the best things about Sanofi Genzyme is the consistently fun and dynamic work environment that I get to be a part of."

Kristin Ouimet Regional Business Manager

"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders

Responsibilities

COMPANY DESCRIPTION:

Genzyme has pioneered the development and delivery of transformative therapies for patients affected by rare and debilitating diseases for over 30 years. These goals are accomplished through world-class research, collaboration with the global patient community, and with the compassion and commitment of our employees.  With a focus on rare diseases and multiple sclerosis, we are dedicated to making a positive impact on the lives of the patients and families we serve.  Genzyme's portfolio of transformative therapies, which are marketed in countries around the world, represent groundbreaking and life-saving advances in medicine. As a Sanofi company, Genzyme benefits from the reach and resources of one of the world's largest pharmaceutical companies, with a shared commitment to improving the lives of patients.

Sanofi, an integrated global healthcare leader, discovers, develops, and distributes therapeutic solutions focused on patients’ needs. Sanofi has core strengths in the field of healthcare with growth platforms in human vaccines, innovative drugs, consumer healthcare, emerging markets, rare diseases, gene therapies and animal health.

JOB OVERVIEW:

The Scientist position for the Pilot Lab in MSAT will work in a matrix team management environment with global engineers and scientists to achieve robust and a scalable processes to support 2nd generation process scale-up, tech transfer and life-cycle management. This position will support a wide variety of molecules and modalities including Enzymes, Antibodies and recombinant proteins.

In concert with Sanofi’s Patient First philosophy, this role will play a key role in developing robust and scalable protein production processes to deliver to the manufacturing group.  As part of the MSAT group this position will also support the manufacturing team to ensure the successful technical transfers to produce pharmaceutical drugs for life saving therapies.

Responsibilities:

  • Work with a global group of engineers and scientists to develop robust and scalable Upstream and downstream processes for monoclonal antibodies, bispecific antibodies, Fc-, Fab-, and fusion proteins, enzymes, and other recombinant proteins to support GMP manufacture

  • Work on MSAT development and pilot-scale projects, to include regular team meetings and updates for, data management, investigations, technical report writing and regulatory filings

  • Support technology transfer including projects for internal and external partners

  • Support DOE studies to establish proven and acceptable process ranges

Basic Requirements/Qualifications:

  • PhD in Biotechnology, or related field, with minimum of 2 years of relevant experience; OR

  • M.S./M.A. in Biotechnology, or related field, with minimum of 5 years of relevant experience; OR

  • B.S./B.A. in Biotechnology, or related field, with minimum of 8+ years of relevant experience

AND

  • Experience with Upstream and/ or Downstream processes at Pilot scale

  • Prior experience in process scaling and or technology transfer

  • Prior experience with automated systems a must

  • Experience with authoring and executing protocols, interpretation of data and generating final reports

  • Experience with ATF perfusion-based systems a plus

  • Experience writing and revising standard operating procedures and batch production records

  • Experience with operating and troubleshooting process equipment

  • Experience working on late phase and commercial programs

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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