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Scientist

Framingham, Massachusetts

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Quote

"One of the best things about Sanofi Genzyme is the consistently fun and dynamic work environment that I get to be a part of."

Kristin Ouimet Regional Business Manager

"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders

Responsibilities

Sanofi’s Neuroinflammation and Repair Research Cluster in the Rare Diseases and Neuroscience Therapeutic Area, based in Framingham, MA, is looking for a highly qualified and motivated Senior Scientist to work in a lab that is working to discovery and develop therapies for the treatment of Progressive Multiple Sclerosis (MS) and other neurodegenerative and neuroinflammatory diseases. The goal of this work is to developing novel strategies to target glial signaling networks to limit disease progression and promote neuroprotection, remyelination and repair. This laboratory-based position will include the opportunity to interact with internal and external collaborators, initiate new drug discovery programs and advance ongoing projects. The candidate must have expertise in neuronal and glial cell cellular biology, deep knowledge of neural-immune and glial signaling pathways and a working knowledge of RNASeq and bioinformatics approaches

Responsibilities:

  • Identify new pathways and targets relevant to neuroinflammatory and neurodegenerative disease and conduct discovery research to validate these pathways and targets in cell culture and animal models and human biosamples.

  • Create new RNAseq and single cell RNAseq databases from human tissue banks and mouse models of disease. Work independently and with Bioinformatics colleagues to identify cell- and disease-specific gene signatures in neurons and glial cells. Develop searchable databases for group members to easily access data.

  • Develop new tools to study neuron-glia and glia-glia signaling in vitro and in vivo using primary rodent and human cell cultures, human iPSC cells, and rodent models of neuroinflammatory and neurodegenerative disease.

  • Perform target validation in human tissue by analyzing gene expression changes, pathway activation/deactivation, and signal localization at the RNA and protein level.

  • Work collaboratively with other members of the group to design and execute studies.

  • Maintain electronic laboratory notebooks, follow good research practices, and develop project deliverables, timelines and resource needs.

  • Develop skill sets needed to become a research project team leader to advance projects from target discovery and validation to lead candidate identification and support Phase 1 and 2 studies.

  • Present research at internal stakeholder meetings and at scientific conferences. Prepare research manuscripts and publish work in peer reviewed scientific journals.

  • Establish and maintain an external scientific network to continue to develop expertise in cutting edge science and technology to support the Rare and Neurologic Diseases Therapeutic Area strategy.

Education:

  • Ph.D. with 1 or more years of academic or industry postdoctoral experience.

  • Background in neuroscience, neuro-immunology, glial biology, and/or neurodegenerative disease is required.

  • Expertise in neurodegenerative and neuroinflammatory disease and experience with cell- and animal-based disease models.

  • Evidence of scientific productivity including first author manuscripts from graduate and postdoctoral training and presentations at scientific conferences.

  • Experience in drug discovery and development preferred but not required.

  • Proficiency in big data analyses including RNAseq and single cell RNAseq. Ability to run analysis pipelines in R or related platforms, and ability to interface with the Bioinformatics group for more complicated analyses.

  • Wet bench proficiency including cell culture, co-cultures, brain tissue dissociation, biochemistry (Western blot, protein pull-down), histology, and live cell and static tissue imaging using epiflourescence and confocal microscopy and image analysis.

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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