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Process Engineer, Continuous Manufacturing Process Design Job at Engineering & Maintenance at Sanofi

Location Framingham, Massachusetts Job Category Engineering & Maintenance Requisition Number POS_00474165-0003JC
Process Engineer, Continuous Manufacturing Process Design-POS_00474165-0003JC


Description
Sanofi Genzyme focuses on developing specialty treatments for debilitating diseases that are often difficult to diagnose and treat, providing hope to patients and their families.

Genzyme Corporation (a Sanofi company) and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

Job Responsibilities/Department Description:

The Continuous Manufacturing Skill Center is a global function within Sanofi whose mission is to develop and implement a commercializable Integrated Continuous Biomanufacturing (ICB) platform in R&D and Industrial Affairs (IA) for the production of therapeutic proteins. ICB provides many important strategic advantages for manufacturing of therapeutic proteins through process intensification, integration and simplification. By working with other Skill Centers, Bioprocess Development and IA, this department is responsible for the development of “state of the art” and innovative technologies required to demonstrate and mature the fully continuous end-to-end protein production platform for therapeutic enzymes, different types of antibodies and other protein products. This group will support implementation for clinical trial and commercial manufacturing in existing facilities as well as in the “factory of the future”. This is an exciting opportunity with the potential to have a significant impact on future manufacturing strategies to be used by Sanofi and the biopharmaceutical industry as a whole.

Downstream Process Chemical Engineer

We are seeking a candidate with chemical engineering skills to assist in the integration of fully continuous downstream biopharmaceutical manufacturing processes and help incorporate process analytical technologies (PAT) for the enablement of robust process understanding and control. This person needs to be a motivated, organized, flexible and creative individual. This person must be a good problem solver and willing to take calculated risks if necessary to achieve the desired goals. This person must be able to establish good working relationships internally, with vendors and with outside collaborators to achieve the desired continuous platform goals. The ideal candidate will help establish working practices for engineering related to continuous protein purification. This is an exciting ground floor opportunity to participate in the implementation of continuous manufacturing into real world applications.

This Chemical Engineering/Scientist position is within the continuous downstream process design group and the ideal candidate would become recognized as a highly credible contributor throughout our worldwide manufacturing and science organizations.






Qualifications

Basic Qualifications:
  • Ph.D. in Chemical Engineering, Biochemical Engineering, Biochemistry or related fields, with a minimum of 0-2 years of relevant industry experience.
  • Application of scientific and technical knowledge in downstream purification processes.
Preferred Qualifications:
  • Ability to work with internal resources and outside collaborators to design, develop and implement solutions to key technologies and gaps for downstream continuous manufacturing.
  • Work well within a fast-paced, dynamic and team-oriented environment.
  • Possess excellent organizational, interpersonal and problem solving skills.
  • Experience with equipment and systems associated with purification processes.
  • Hands on experience with AKTA and protein purification including chromatography, virus inactivation, ultrafiltration and filtration unit operations.
  • Experience with Design of Experiments (DOE) approach for process development and characterization.
  • Experience with multivariate analysis.
  • Experience in process development and technology transfer.
  • A solid understanding of Good Manufacturing Practices (cGMPs), particularly as they relate to the downstream processing.
  • Work with minimal supervision; perform basic analysis such as HPLC-SEC, SDS-PAGE and ELISA’s.
  • Analyze and interpret data and present results at meetings.
  • Provide reports and prepare scientific presentations as needed.
  • Write technical and monthly reports as necessary.
  • Interact with senior members of the other functional groups including Upstream Process, Analytical Development, Quality and IA.
  • Other experience with DeltaV, MatLAB and BioSolve would be considered beneficial.

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Job : Engineering & Maintenance
Primary Location : United States-Massachusetts-Framingham


Job Posting : Dec 16, 2016, 4:18:21 PM

Job Type : Regular
Employee Status : Regular