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Principal Scientist

Framingham, Massachusetts



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Culture: Play to Win

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  • Health & Wellness

    Comprehensive coverage including medical, dental, vision, and health and wellness programs.

  • Financial

    Sanofi wants to ensure employees are equipped for financial health, Sanofi provides a competitive 401K Match program and Financial Wel-Being Tools and Programs.

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    At Sanofi, we demonstrate our commitment to inclusion and diversity through Culture groups and programs. There are many ways to make a difference and connect with other Sanofi employees: including ERG groups and 2 PAID days off to Volunteer.

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    Sanofi provides significant Work/Life benefits to help you excel beyond the workday. Including Workplace Flexibility through part‑time, remote work, flex‑time and job share options.

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"One of the best things about Sanofi Genzyme is the consistently fun and dynamic work environment that I get to be a part of."

Kristin Ouimet Regional Business Manager

"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders


Position Overview:

Sanofi is searching for a Lab Head in the Rare & Neurologic Diseases Research Therapeutic Area who will develop cutting-edge therapeutics for common neurodegenerative disorders and rare diseases, including metabolic, renal, hematological, muscle, and neurological disorders.

We are seeking a scientific innovator with demonstrated expertise in either lysosomal biology, autophagy, oxidative stress, lipid, amino acid or carbohydrate metabolism, predominantly related to neurodegenerative, metabolic and/or muscle diseases. The successful candidate will demonstrate a robust publication track record in leading journals and presentations at national and international meetings.

The Lab Head will drive leading edge Science in his/her area of expertise, advance portfolio projects, manage a group of PhD scientists and technical staff, and collaborate with multidisciplinary platform groups. He/she will identify and validate new therapeutic targets using human genetics, bioinformatics, and preclinical in vitro and in vivo models of disease. The successful candidate will also be responsible for developing and implementing new models and technologies. The Lab Head will also be responsible for communicating their research results through presentations, publications, and patents.

Key Accountabilities:

  • Support the Rare & Neuroscience Therapeutic Area strategy by identifying new targets and advancing projects in the current pipeline.

  • Implementation of multiple state-of-the-art techniques in molecular and cell biology, and imaging.

  • Lead scientists and technical staff experienced in a range of disciplines, from molecular and cell biology, neuropharmacology, histopathology, and behavioral phenotyping to develop a deep mechanistic understanding of disease pathogenesis.

  • Publish cutting edge science and develop key collaborations around the globe.

Basic Qualifications:

  • Ph.D. in molecular/cell biology or physiology, neuroscience, pharmacology or related discipline, with 5+ years postdoctoral training.

  • Experience leading research teams in an academic or industry setting preferred.

  • Deep expertise and outstanding record of publications.

  • Expertise in cutting-edge approaches in cell biology, transcriptomics, lipidomics, metabolomics, proteomics, bioinformatics, data mining and other approaches to identify and validate new targets.

  • Experience preferred in one or more of the following areas: small molecule drug discovery, targeted drug or protein or nucleic acid delivery

  • Outstanding communication, management and interpersonal skills.

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. This position will require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.



At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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