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Laboratory Head, Senior Principal Scientist, Non-viral Gene Therapy, Genomic Medicine Unit

Framingham, Massachusetts



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Laboratory Head, Senior Principal Scientist, Non-viral Gene Therapy, Genomic Medicine Unit

We are seeking a Laboratory Head, Senior Principal Scientist, to join the newly created non-viral gene therapy research group in the Genomic Medicine Unit. The candidate will play a leadership role in establishing and executing the strategy to develop targeted non-viral gene therapy treatments for rare and common diseases across various therapeutic areas.

Specifically, the remit of the candidate will be to:

  • Build and implement a high throughput screening (HTS) platform for LNP targeting to various tissues
  • Applying scientific expertise and judgement to initiate, design, direct and execute engineering of targeted nanoparticles to tissues to deliver DNA and mRNA cargo, working cross-functionally with biology project teams
  • Be an integral part of biology teams to enable progression of drug candidates to the clinic
  • Contribute to formulations while working cross-functionally with CMC and chemistry
  • Act as an impactful contributor and leader of project teams and transverse and cross-functional initiatives.
  • Work across R&D organization to test and advance innovative processes, hypotheses, and methodologies
  • Enable productivity, execution with a sense of urgency, teamwork, accountability, scientific rigor, and excellence.
  • Foster a culture of employee growth and development


  • Leading-edge knowledge of principles, concepts, and practices in non-viral gene delivery (specifically to LNPs); with a focus on portfolio advancement
  • PhD plus minimum 3 years of relevant research experience in an academic or biopharmaceutical setting demonstrating continuous growth in depth and breadth of knowledge
  • Applies technical, functional and industry knowledge to design and execute projects that shape the strategic direction of the group.
  • Proven ability of foresight and judgement in planning, organizing ,and guiding complex projects.
  • Track record of successfully applying high- level scientific judgement in a variety of complex and unprecedented situations.
  • Flexibility to rapidly changing priorities and deadlines and ability to lead others through change in a dynamic, fast paced industry and work environment.
  • Recognized as a rising star scientist in the field.  Outstanding track record of scientific publications, presentations, as a leading contributor. 
  • Excellent track record of project impact as a key contributor.
  • Excellent interpersonal and communication skills: impactful oral and written communication.
  • Experience in preparing high quality documents including technical reports, presentations, SOPs, experimental protocols and regulatory filings.
  • Candidates must be authorized to work in the USA.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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