Skip to main content

Lab Head Technical Pilot Plant Upstream

Framingham, Massachusetts

Apply for role


From Research and Development to Sales and Marketing, Sanofi offers a wide range of possibilities. Discover our open positions and become a health journey partner.

Back to Job Navigation (Overview)

Success Profile

Do you have what it takes for a successful career with Sanofi?

  • Courageous
  • Results-driven
  • Proactive
  • Problem-Solver
  • Leadership
  • Team player

Back to Job Navigation (Success)

Culture: Play to Win

  • Woman looking through a microscope


  • Scientists discussing lab work


  • Doctor using new technology


  • Woman using dry eraser marker drawing up business plans on glass



  • Health & Wellness

    Comprehensive coverage including medical, dental, vision, and health and wellness programs.

  • Financial

    Sanofi wants to ensure employees are equipped for financial health, Sanofi provides a competitive 401K Match program and Financial Wel-Being Tools and Programs.

  • Culture

    At Sanofi, we demonstrate our commitment to inclusion and diversity through Culture groups and programs. There are many ways to make a difference and connect with other Sanofi employees: including ERG groups and 2 PAID days off to Volunteer.

  • Work/Life Balance

    Sanofi provides significant Work/Life benefits to help you excel beyond the workday. Including Workplace Flexibility through part‑time, remote work, flex‑time and job share options.

Back to Job Navigation (Rewards)


"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders



We are seeking a highly motivated individual to join the BioProcess Engineering (BPE) department, part of the Sanofi Global CMC Development organization, in the role of Lab Head Technical Pilot Plant Lab Upstream. This role is accountable for Technical Pilot Plant (TPP) upstream production for early and late stage fed batch and continuous biologics production for monoclonal antibodies and other biological therapeutics.  The role will work with the BPE teams to produce candidate molecules under development to support CMC and technical transfer activities. The Lab Head TPP Upstream will interface with the USP BioProcess development and BPE DSP teams to transfer processes into the TPP for biological production at the 100L/500L scale.  The role will oversee the readiness of the TPP USP equipment and process development studies and interface with Drug Substance teams.

Key Responsibilities

  • Oversee And participate in USP TPP team production of MAB and other Biological therapeutics at the 500L scale (MAB) and 100L/500L scale (Continuous).

  • Ensure process equipment readiness and update process equipment with the Engineering group.

  • Evaluate new process platforms and manufacturing technologies for potential implementation with BioProcess development and BPE Tech transfer groups.

  • Responsible for production batch record generation.  Responsible for updating molecule specific documentation and process SOP’s.

  • Participate in regular review meetings during development campaigns with updates on process performance, deviations, and root causes.

  • Assist in Technical Pilot Plant build out final design and equipment purchase.

  • Act as cell culture Subject Matter Expert (SME) to BPE and development groups. 

  • Work collaboratively with other functions to streamline ways of working.

  • Maintain and update the BPE knowledge base of equipment and operation specifications.

  • Implement digital documentation systems for cell culture processes.

Basic Qualifications

  • PhD in Chemical Engineering, Biochemistry, Biotechnology, or related discipline with 4 years’ experience or a master’s degree with 8 years or Bachelor's degree with 10 years of relevant industry experience in manufacturing, Pilot Plant, and/or process development of biologics

  • Experience in leading teams.

  • Excellent communication skills

  • Experience working on multiple complex projects to aggressive timelines with the ability to adapt to rapid changes in project priorities.

  • Experience in manufacturing or process development of biologics with mammalian cell culture

  • Knowledge on scale-up, process transfer, and cGMP manufacturing operation.

Preferred Qualifications

  • Experience in writing and revising protocols, procedures, reports, and other process related documentation as necessary to support process scale-up, implementation.

  • Experience with Delta-V or other manufacturing control systems.

  • Working knowledge in recombinant protein GMP manufacturing, quality standards, and regulatory requirements

  • Experience in defining process control strategy and performing risk assessment following the QbD principle

Special Working Conditions

  • Ability to gown and work in manufacturing areas

  • Ability to work flexible hours, rotation support of weekend cell culture operations.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

Apply for role
Your jobs

You have not recently viewed any jobs.

You have not saved any jobs.

Sign Up for Job Alerts

Don't see what you're looking for? Sign Up and we'll notify you when roles become available.

Areas of InterestEnter a location and a category and click 'Add' to create your Job Alert.