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Principal Scientist - Lab Head, Checkpoint Immunology

Cambridge, Massachusetts

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"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders


Principal Scientist (Lab Head), Checkpoint Immunology

The Immunology and Inflammation Research Therapeutic Area in Sanofi is seeking highly motivated scientist to lead projects evaluating novel therapies in the fields of Immune Checkpoint Biology to treat autoimmune and inflammatory diseases.  The scientist will lead new drug discovery programs from the early stage to the identification and validation of a clinical candidate.  The successful candidate will have deep expertise in Immunology, autoimmune disease biology, and a demonstrated track record in leading scientific and/or drug discovery programs.

The successful candidate will be the biology lead for various Checkpoint-based therapeutic programs. She/He will design and execute experiments to validate checkpoint targets for various I & I prioritized indications. The candidate will work in a matrixed environment and collaborate extensively with multidisciplinary platform groups to advance the portfolio projects.

Key Responsibilities:

  • Responsible for applying scientific expertise and judgement to initiate, design and execute preclinical studies to validate the target and to support the project transitions in timely fashion.

  • Promotes the use of novel experimental approaches within Checkpoint immunology and project team; routinely investigates/creates innovative processes, hypotheses and methodologies. Developing own strategy for drug discovery.

  • Collaborate with Immunology and Inflammation Bioinformatics Team to identify and validate therapeutic targets.

  • Provide scientific expertise, establish and manage external scientific collaborations, monitor the external market, and provide critical project assessments.

  • Makes decisions that frequently require developing new options to solve moderately complex problems. Works in ambiguous situations within therapeutic area/platform.

  • Uses a high level of scientific judgement to adapt and/or create standard methods and techniques by applying breadth of knowledge and prior work experience.

  • Works independently on assignments using knowledge and work experience. Gathers input from colleagues and management to address issues at therapeutic area level.

  • Provide and promote support for operational excellence according to Sanofi values and ethics.

  • Prepare publications, research and clinical/regulatory documentation in accordance with Sanofi quality standards.

Basic Qualifications:

  • PhD plus a minimum of 5 years of relevant experience preferably in pharma/biotech set up.

  • Leading edge knowledge of Checkpoint Immunology including co-inhibitory/-stimulatory pathway biology, T/B or innate immunity and relevant experience in the immunology/inflammation-related disease areas.

  • Candidate should possess a strong understanding of biological concepts, mechanistic elucidation, and phenotypic workflows coupled with a strategic vision of novel target drug discovery 

  • Demonstrated track-record of successful project leadership, and the leadership and mentorship of junior colleagues is required

  • Expertise in various in vitro immunological assays and in vivo inflammatory models is required.

  • Outstanding track record of scientific publications, presentations, patents, projects as a leading contributor or senior author. 

  • Established track record of leading drug discovery programs would be preferred.

  • Flexibility to adopt to a rapidly to changing priorities and deadlines and ability to lead others through change in a dynamic, fast paced industry and work environment.

  • Excellent interpersonal and communication skills: impactful oral and written communication.

At Sanofi R&D North America, we deliver meaningful solutions for patients. We transform science into breakthrough, best-in-class and first-in-class medicines and vaccines. We believe in creating a diverse and inclusive workforce – and workplace – which brings together the collective brainpower of over 2,000 colleagues and provides you with an exciting place to grow and develop. We set the bar high, and we deliver. Join us and together we will build on our trusted legacy of breakthroughs for society. 

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.


At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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