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Postdoctoral Fellowship: Molecular Oncology

Cambridge, Massachusetts



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Job Title: Post Doc: Molecular Oncology

Hiring manager: Zhihu (Jeff) Ding. ( )

Sanofi Molecular Oncology is seeking a highly motivated and talented PhD scientist for the position of Post Doc, based in Cambridge, Massachusetts, USA.  The project will perform CRISPR knockout screen by using a genome-scale CRISRP gRNA lentiviral library and to validate a prioritized list of novel cancer cell dependency targets for drug-resistant breast cancer. The project will focus on oncology-relevant targets and will involve close collaboration with chemical biology, biochemistry and bioinformatics groups. The candidate should have a PhD in a relevant area (biochemistry, molecular/cellular biology) and have an interest in the field of oncology and proteasomal degradation.

Position Overview/ Key Responsibilities:

  • Works as part of a research team to identify and validate key drivers in drug-resistant breast cancer
  • Performs CRISPR knockout screen by using a genome-scale CRISRP gRNA lentiviral library
  • Validate a prioritized list of novel cancer cell dependency targets for drug-resistant breast cancer
  • Collaborates closely with colleagues in other functional areas (i.e. Chemical Biology, Biochemistry and Bioinformatics)
  • Independently designs, performs and interprets experiments
  • Summarizes data by writing procedures/protocols and generating presentation material
  • Presents data and experimental designs internally (at lab, group and global project team meetings) and externally (at international conferences)
  • Compiles and publishes first-author publications

Basic Qualifications:

  • Ph.D. in molecular biology or biochemistry with emphasis in oncology
  • Extensive hands-on expertise in cell culture and standard molecular biology methods  (including siRNA, shRNA and CRISPR/Cas9)
  • Expertise in molecular cloning, including CRISPR knock-out/knock-in strategies preferred
  • Previous experience in CRISPR knockout screen is desirable
  • Proven track  record of expertise in oncology, as evidenced by peer-reviewed publications in a high-quality journal
  • Ability to work in cross-disciplinary teams to generate hypothesize and validate them
  • Motivated, detail-oriented, with a passion for science
  • Ability to drive and develop the project independently
  • Excellent communication and record keeping skills
  • Ability to work in a high-pace and dynamic scientific environment
  • All candidates must have permanent US work authorization. No visa sponsorship will be provided.

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