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B Cell Immunology, Principal Scientist - Vaccine

Cambridge, Massachusetts

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"At Sanofi, We are guided by a deep appreciation and understanding of what it means to live with a rare blood disorder, and we learn by listening to the community – patients, caregivers physicians, and other healthcare professionals."

Shannon Resetich US Head Rare Diseases & Blood Disorders

"Patients are at the center of all that we do at Sanofi. Our teams are focused on advancing transformational therapies that can address serious unmet needs for people living with rare blood disorders, and expanding global patient access to our medicines."

Mouhamed Gueye US Head Medical Rare Blood Disorders


B cell immunology, Principal Scientist

Global Immunology, Sanofi Vaccines R&D, Cambridge, MA

Job Description

We are seeking a talented technical lead to evaluate immune responses to the infectious disease vaccine candidates from the bench to the bedside. Candidate must have a broad working knowledge of immunology, with a preferred focus on B cell immunology, of applicable microfluidic-based characterization methods and be able to apply that knowledge independently and creatively toward the development of novel protocols to define the biomarkers of immunity and advance rational design for vaccine candidates. Successful candidate will help drive the scientific and technical strategy for multiple programs, including the development of high dimensional flow cytometry and 10X Genomics tools for deep profiling of antigen-specific T and B cells in multiple contexts.  Candidate will have exceptional ability to design, execute, analyze and troubleshoot complex experiments and train junior scientists. Individual must be a self-starter, strategic thinker, possess ability to work in a matrix organization and to change direction and methods if required.

Job Responsibilities

  • Independently propose, design, develop and oversee execution of studies to enable high quality analysis of vaccine responses and train others as required

  • Provide scientific leadership in the team to develop and evaluate workflows for B cell responses and mAb discovery and characterization activities to support ongoing projects

  • Oversee and participate in lab work to support research studies: develop design, experimental plans, hypotheses, evaluate and interpret data, write reports, present results

  • Lead tech transfer of technical methodologies to other sites and/or cross-functional internal or external groups as required

  • Bring forth new ideas, techniques, and technology to ensure that the group remains at the forefront of the innovation in the field to best serve the projects

  • Participate in timeline planning and decision-making regarding research priorities and provide information on feasibility of prospective projects

  • Present findings to the teams, management, and multidisciplinary groups internally and externally to the collaborators and at the conferences


  • PhD in Immunology, Molecular Biology (or related discipline), 5+ years of postdoctoral experience, M.Sc. with 8+ years of relevant experience. Additional experience in pharma industry is a plus

  • Ability to demonstrate leadership and success guiding B cell characterization methodologies from concept phase through implementation

  • Deep understanding of and hands-on experience with flow cytometry, cell sorter and 10x Genomics® Chromium™ system as well as sequence data analysis

  • Expertise in developing, optimizing, and troubleshooting antibody panels for novel analytical flow assays

  • Hands-on experience in isolation, handling and characterization using multicolor flow cytometry of primary cells

  • Deep knowledge in multi-parameter flow cytometry analysis

  • Extensive hands-on experience with B cell isolation. Previous experience with mAb discovery is highly desirable.

  • Experience working in a matrix environment and supporting one or more projects simultaneously

  • Excellent time management skills, ability to prioritize work and to drive project activities forward

  • Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, strong motivation with a dedicated work ethic

  • Vast expertise in immunology with a preferred focus on B cell immunology and with record of scientific achievement (strong publication and/or patent, IND filing record)

  • Sound judgement, excellent verbal and written communication skills and ability to provide recommendations around complex scientific results

  • Compliance with all safety training and good research laboratory practices

  • Experience working in Pharma, biotech industry

  • Experience identifying and managing work with CROs

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. All US based roles require individuals to be fully vaccinated against COVID-19 as part of your job responsibilities.

According to the CDC, an individual is considered to be “fully vaccinated” fourteen (14) days after receiving (a) the second dose of the Moderna or Pfizer vaccine, or (b) the single dose of the J&J vaccine. Fully vaccinated, for new Sanofi employees, is to be fully vaccinated 14 DAYS PRIOR TO START DATE.


At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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