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Senior Scientist

Framingham, Massachusetts



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Position Overview:

The Translational Sciences Group in Sanofi strives to generate scientific knowledge that translates into transformative therapies for patients with unmet medical needs.  Translational Sciences is building a world-class Proteomics & Metabolomics team that is passionate to contribute to the discovery and development of novel therapeutics for patients.  Translational Sciences Proteomics & Metabolomics team is seeking highly motivated Metabolomics and Lipidomics Scientist to join the multidisciplinary team to apply novel Metabolomics as well as Lipidomics approaches to various internal, external and  consortia studies.  Seeking a highly motivated Lipidomics Scientist to join Proteomics and metabolomics group Cambridge/Framingham, MA which is part of Translational Sciences in R&D. Seeking a highly motivated Metabolomics/Lipidomics Scientist to join Proteomics and Metabolomics group in Cambridge/Framingham, MA which is part of Translational Sciences in R&D. The successful candidate will be an expert in analytical chemistry, metabolomics, and biomarker development, and has experience operating in a matrixed drug discovery environment.

He/She will manage collaborations with TA projects and be able to work independently on small molecule biomarker discovery and analysis. In this position, the senior scientist will also be responsible for evaluation and employment of the emerging cutting-edge metabolomic technologies as well as for maintaining operational readiness of the equipment.  This exciting role will afford talented scientist the opportunity to translate their data-integration and analytical abilities into novel actionable hypotheses.

Key Responsibilities:

  • Run untargeted/targeted metabolomics approaches to support the teams' biomarker strategies, goals and timelines.

  • In conjunction with functional and program team members design and execute exploratory metabolomics experiments to elucidate mechanistic links between target engagement and disease phenotypes.

  • Mass spec data processing, analysis, and organizational capabilities are central to the position; beyond operation of commercial mass spec software, this will include extensive use of peak picking and omics data software.

  • Work with other scientists on integrating multi-omics data.

  • Develop targeted and quantitative LC-MS assays for metabolite biomarkers.

  • LC-MS assay development, implementation, optimization and routine maintenance.  

  • Collaborate with group members and cross-functional teams to support biomarker analysis, target identification, and MOA studies.

  • Evaluate and develop new technologies to streamline and improve the efficiency of the workflows.

  • Author technical reports, study protocols and manuscripts for publication; present at internal and external meetings and conferences.

Basic Qualifications:

  • PhD in Analytical Chemistry, Biochemistry or a related discipline with at least 2 yr industry experience, or a master’s degree with a minimum of 3 years of industry experience.

  • Strong track record of independent and in-depth mass spectrometry characterization and quantitation of small molecules and lipids.

  • Extensive method development experience in metabolomics, lipidomics, and targeted mass spectrometry assays for small molecule quantitation.

  • Highly motivated, organized, detail-oriented and able to work in a fast-paced environment and must be able to work in a team-oriented environment.

  • Strong written and verbal communication skills are essential. Desire to function successfully in a cross-functional, matrix-based research organization.

  • Must be able to work in a team-oriented environment and demonstrate attention to detail and record-keeping.

  • Strong communication and inter-personal skills.

Preferred Qualifications:

  • Demonstrated experience in working in matrixed environment or as member of small team of PhD and MS level scientist to contribute to drug discovery and development programs.

  • Experience in metabolomics or lipidomics is highly desired.

  • Hands on experience with Q-Exactive instrumentation is preferred.

  • An impactful publication track record that clearly articulates scientific contributions in the field of genetics and computational biology.

  • Industry experience.

  • Comprehensive understanding of lipid biochemistry in the areas of systems biology, neurodegeneration, immunology & inflammation and cancer is a plus.

  • Excellent written and oral communication skills.

  • Excellent interpersonal and team skills.

  • Self-driven.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.




At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.

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